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5-HTP

Moderate Evidence
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Overview

Form
capsule
Category
Amino Acid

Budget,Moderate evidence for anxiety; caution with antidepressants

Supported Health Goals

Anxiety Relief

Limited Evidence

Reduction of anxiety symptoms and stress management

Moderate evidence, caution with SSRIs/MAOIs

Mood Support

Limited Evidence

Support balanced mood and emotional wellbeing

Moderate evidence, caution with antidepressants

Scientific Studies (2)

Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.

Primary
Gastroenterology· 2022· n=126· rct

Improved fatigue in quiescent IBD patients vs placebo

View Study →

Tryptophan and 5-hydroxytryptophan for depression.

Cochrane Database Syst Rev· 2002· systematic review

Limited evidence for depression improvement; insufficient quality for firm conclusions

View Study →

Safety & Interactions

⚠️ Severe Interactions Detected

Please consult a healthcare provider before using this supplement with other medications or supplements.

life threatening Interaction

May cause serotonin syndrome - life-threatening condition

Recommendation: DO NOT COMBINE - Serious risk of serotonin syndrome

life threatening Interaction

May cause serotonin syndrome - life-threatening condition

Recommendation: DO NOT COMBINE - Serious risk of serotonin syndrome

severe Interaction

May cause serotonin syndrome

Recommendation: Avoid combination, seek medical guidance

severe Interaction

May cause serotonin syndrome

Recommendation: Avoid combination, seek medical guidance

moderate Interaction

May cause serotonin syndrome

Recommendation: Avoid combination with DXM-containing products

life threatening Interaction

Combination may increase risk of serotonin syndrome

Recommendation: Avoid combination. Use one at a time.

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