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Caffeine

Strong Evidence
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Overview

Form
capsule
Category
Stimulant

Budget,Energy,focus,exercise performance

Supported Health Goals

Energy & Fatigue

Strong Evidence

Boost energy levels and reduce fatigue

Well-established energy and focus enhancement

Exercise Performance

Strong Evidence

Enhance athletic performance and recovery

Well-established performance enhancement

Scientific Studies (3)

Caffeine Use in Sport: A Systematic Review and Meta-analysis of Acute Side Effects and Implications for Athlete Health and Safety.

Primary
Sports medicine (Auckland, N.Z.)· 2026· meta analysis

Documented acute side effects in sport

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Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial.

Primary
JAMA· 2026· n=30· rct

Improved reaction time and alertness in sleep-deprived military personnel

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Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.

Primary
Sleep medicine reviews· 2017· meta analysis

Improved endurance performance and power output in athletes

View Study →

Safety & Interactions

⚠️ Severe Interactions Detected

Please consult a healthcare provider before using this supplement with other medications or supplements.

moderate Interaction

May reduce antidepressant effectiveness

Recommendation: Monitor mood, limit caffeine intake

mild Interaction

May reduce sedative effectiveness

Recommendation: Avoid close timing

moderate Interaction

May reduce beta blocker effectiveness

Recommendation: Monitor blood pressure, limit caffeine

moderate Interaction

Additive stimulant effects

Recommendation: Avoid combination or limit caffeine

mild Interaction

May reduce antipsychotic effectiveness

Recommendation: Monitor symptoms, limit caffeine

moderate Interaction

L-Theanine smooths caffeine's stimulant effects, improving focus without jitters

Recommendation: Recommended stack: 100-200mg L-Theanine + 50-100mg caffeine

severe Interaction

Additive stimulant effects may cause cardiovascular stress

Recommendation: Avoid combination, cardiovascular risk

moderate Interaction

Both are stimulating, may cause overstimulation

Recommendation: Monitor for anxiety or jitters, may reduce doses

mild Interaction

Ashwagandha may help buffer caffeine's stimulant effects

Recommendation: May be helpful combination for some

mild Interaction

May have mild synergy for focus

Recommendation: May be beneficial combination for focus

moderate Interaction

Enhanced performance and focus

Recommendation: Good pre-workout combination

moderate Interaction

Enhanced focus and pump during exercise

Recommendation: Good pre-workout stack

moderate Interaction

Enhanced performance and focus

Recommendation: Good pre-workout combination

moderate Interaction

Caffeine may interfere with melatonin's sleep-promoting effects

Recommendation: Avoid taking close to bedtime, separate by several hours

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