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Vitamin K2

Strong Evidence
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Overview

Form
capsule
Category
Vitamin

Budget,Bone and cardiovascular health

Supported Health Goals

Heart Health

Strong Evidence

Support cardiovascular system function

Cardiovascular and bone health

Scientific Studies (4)

Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial.

Primary
JAMA internal medicine· 2024· n=199· rct

Reduced nocturnal leg cramp frequency and severity vs placebo

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The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial.

Primary
European journal of clinical nutrition· 2022· rct

Reduced vascular calcification in pediatric hemodialysis patients

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Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study.

Primary
Journal of the American Society of Nephrology : JASN· 2020· n=558· rct

Reduced vascular calcification in hemodialysis patients when combined with rivaroxaban

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Effects of vitamin K2 supplementation on atherogenic status of individuals with type 2 diabetes: a randomized controlled trial.

BMC complementary medicine and therapies· 2021· rct

Improved atherogenic status in type 2 diabetes patients

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Safety & Interactions

⚠️ Severe Interactions Detected

Please consult a healthcare provider before using this supplement with other medications or supplements.

severe Interaction

Directly counteracts warfarin - bleeding risk

Recommendation: AVOID with warfarin - maintain consistent diet

mild Interaction

May reduce effectiveness

Recommendation: Monitor with healthcare provider

moderate Interaction

Vitamin K2 directs calcium to bones, while D3 aids absorption

Recommendation: Recommended stack for bone and cardiovascular health

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