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Ashwagandha

Strong Evidence
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Overview

Form
capsule
Category
Herbal

Meta-analysis shows significant reduction in anxiety (HAM-A) and cortisol levels

Supported Health Goals

Anxiety Relief

Strong Evidence

Reduction of anxiety symptoms and stress management

Meta-analysis of 15 RCTs with 873 patients

Mood Support

Strong Evidence

Support balanced mood and emotional wellbeing

Significant anxiety and stress reduction

Scientific Studies (3)

Efficacy and safety of ashwagandha root extract for anxiety and stress: a randomized, double-blind, placebo-controlled trial.

Primary
Cureus· 2023· n=100· rct

Significant reduction in anxiety and improved sleep quality vs placebo

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Ashwagandha supplementation for anxiety and stress: A systematic review and meta-analysis.

Primary
Phytotherapy Research· 2022· meta analysis

Significant reduction in anxiety and stress scores vs placebo across 12 RCTs

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An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.

Primary
Medicine (Baltimore)· 2019· n=60· rct

Reduced stress and cortisol levels vs placebo over 60 days

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Safety & Interactions

moderate Interaction

Ashwagandha has immunostimulatory effects and may reduce efficacy of immunosuppressants

Recommendation: Monitor immune markers closely, avoid without medical supervision

moderate Interaction

May increase thyroid hormone levels

Recommendation: Monitor TSH levels, adjust thyroid medication dosage

moderate Interaction

May enhance sedative effects

Recommendation: Use with caution, monitor for excessive drowsiness

moderate Interaction

Enhanced stress reduction through multiple pathways

Recommendation: Good stress management combination

moderate Interaction

Both are adaptogens, may be overstimulating for some

Recommendation: Monitor for overstimulation, consider lower doses

moderate Interaction

Enhanced anxiety and stress reduction

Recommendation: Good anxiety support combination

mild Interaction

Ashwagandha may help buffer caffeine's stimulant effects

Recommendation: May be helpful combination for some

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Reviews

5.0

1 reviews

T
Test UserMay 2, 2026

Great supplement, really helps with stress.

0 people found this helpful