What is Melatonin used for?

Melatonin is commonly used for: Sleep Quality. These uses are supported by scientific evidence at various levels.

Does Melatonin have interactions?

Yes, Melatonin has 9 known interaction(s). Always consult a healthcare provider before combining supplements.

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Melatonin

Strong Evidence

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Overview

Form: capsule
Category: Hormone

Effective for sleep onset,jet lag; mixed results for sleep maintenance

Supported Health Goals

Sleep Quality

Strong Evidence

Improve sleep onset, duration, and quality

Effective for sleep onset and jet lag

Scientific Studies (2)

Melatonin for sleep onset insomnia: a meta-analysis.

Primary

PLoS One· 2020· meta analysis

Reduced sleep onset latency and increased total sleep time vs placebo

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Melatonin for sleep disturbances in adults: a systematic review and meta-analysis.

Sleep Medicine Reviews· 2024· meta analysis

Confirmed effectiveness for sleep onset; moderate evidence for sleep maintenance

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Safety & Interactions

mild Interaction

May enhance anticoagulant effects

Recommendation: Monitor INR levels, consider lower melatonin dose

moderate Interaction

May cause additive drowsiness

Recommendation: Monitor for excessive drowsiness, adjust timing

mild Interaction

May enhance immune function

Recommendation: Monitor immune function, use with caution

moderate Interaction

Enhanced sleep support through different mechanisms

Recommendation: Popular sleep stack combination

moderate Interaction

Melatonin helps sleep onset, L-Theanine promotes relaxation

Recommendation: Good sleep stack combination

moderate Interaction

Complementary sleep enhancement mechanisms

Recommendation: Good sleep stack combination

moderate Interaction

Caffeine may interfere with melatonin's sleep-promoting effects

Recommendation: Avoid taking close to bedtime, separate by several hours

moderate Interaction

Rhodiola may be stimulating and interfere with sleep

Recommendation: Take Rhodiola in morning, melatonin at night

moderate Interaction

Enhanced sleep support through different mechanisms

Recommendation: Good sleep stack, may cause morning grogginess

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